Autoimmune disorders
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Autoimmune disorders

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An autoimmune disorder occurs when the body’s immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of autoimmune disorders.

The white blood cells in the body’s immune system help protect against harmful substances. Examples include bacteria, viruses, toxins, cancer cells, and blood and tissue from outside the body. These substances contain antigens. The immune system produces antibodies against these antigens that enable it to destroy these harmful substances.

When you have an autoimmune disorder, your immune system does not distinguish between healthy tissue and antigens. As a result, the body sets off a reaction that destroys normal tissues.

The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.

An autoimmune disorder may result in:

  • The destruction of body tissue
  • Abnormal growth of an organ
  • Changes in organ function

An autoimmune disorder may affect one or more organ or tissue types. Areas often affected by autoimmune disorders include:

  • Blood vessels
  • Connective tissues
  • Endocrine glands such as the thyroid or pancreas
  • Joints
  • Muscles
  • Red blood cells
  • Skin

A person may have more than one autoimmune disorder at the same time. Common autoimmune disorders include:

  • Addison's disease
  • Celiac disease - sprue (gluten-sensitive enteropathy)
  • Dermatomyositis
  • Graves' disease
  • Hashimoto's thyroiditis
  • Multiple sclerosis
  • Myasthenia gravis
  • Pernicious anemia
  • Reactive arthritis
  • Rheumatoid arthritis
  • Sjogren syndrome
  • Systemic lupus erythematosus
  • Type I diabetes

I Would Like to Learn About:

  • Causes

    The white blood cells in the body’s immune system help protect against harmful substances. Examples include bacteria, viruses, toxins, cancer cells, and blood and tissue from outside the body. These substances contain antigens. The immune system produces antibodies against these antigens that enable it to destroy these harmful substances.

    When you have an autoimmune disorder, your immune system does not distinguish between healthy tissue and antigens. As a result, the body sets off a reaction that destroys normal tissues.

    The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.

    An autoimmune disorder may result in:

    • The destruction of body tissue
    • Abnormal growth of an organ
    • Changes in organ function

    An autoimmune disorder may affect one or more organ or tissue types. Areas often affected by autoimmune disorders include:

    • Blood vessels
    • Connective tissues
    • Endocrine glands such as the thyroid or pancreas
    • Joints
    • Muscles
    • Red blood cells
    • Skin

    A person may have more than one autoimmune disorder at the same time. Common autoimmune disorders include:

    • Addison's disease
    • Celiac disease - sprue (gluten-sensitive enteropathy)
    • Dermatomyositis
    • Graves' disease
    • Hashimoto's thyroiditis
    • Multiple sclerosis
    • Myasthenia gravis
    • Pernicious anemia
    • Reactive arthritis
    • Rheumatoid arthritis
    • Sjogren syndrome
    • Systemic lupus erythematosus
    • Type I diabetes
  • Symptoms

    Symptoms will vary based on the type and location of the faulty immune response. Common symptoms include:

    • Fatigue
    • Fever
    • General ill-feeling (malaise)
    • Joint pain
    • Rash
  • Exams and Tests

    The health care provider will do a physical exam. Signs depend on the type of disease.

    Tests that may be done to diagnose an autoimmune disorder may include:

    • Antinuclear antibody tests
    • Autoantibody tests
    • CBC
    • Comprehensive metabolic panel
    • C-reactive protein (CRP)
    • Erythrocyte sedimentation rate (ESR)
    • Urinalysis
  • Treatment

    The goals of treatment are to:

    • Reduce symptoms
    • Control the autoimmune process
    • Maintain the body's ability to fight disease

    The treatments your doctor suggests will depend on your disease and symptoms. Types of treatments include:

    • Supplements to replace a substance that the body lacks, such as thyroid hormone, vitamin B12, or insulin, due to the autoimmune disease
    • Blood transfusions if blood is affected
    • Physical therapy to help with movement if the bones, joints, or muscles are affected

    Many people take medicines to reduce the immune system's abnormal response. These are often called immunosuppressive medicines. Examples include corticosteroids (such as prednisone) and nonsteroid drugs such as azathioprine, cyclophosphamide, mycophenolate, sirolimus, or tacrolimus.

  • Outlook (Prognosis)

    The outcome depends on the disease. Most autoimmune diseases are chronic, but many can be controlled with treatment.

    Symptoms of autoimmune disorders can come and go. When symptoms get worse, it is called a flare-up.

  • Possible Complications

    Complications depend on the disease. Medicines used to suppress the immune system can cause severe side effects, such as higher risk of infections.

  • When to Contact a Medical Professional

    Call your health care provider if you develop symptoms of an autoimmune disorder.

  • Prevention

    There is no known prevention for most autoimmune disorders.

Related Information

Immune responseToxinsCancerAntibodyAntigenAllergiesEndocrine glands...Chronic thyroiditi...Pernicious anemia...Addison disease

References

Goronzy JJ, Weyand CM. The innate and adaptive immune systems. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 44.

Kono DH, Theofilopoulos AN. Autoimmunity. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 20.

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Review Date: 7/16/2013

Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

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